Diabetes insípida nefrogénica: diagnóstico en un hospital de mediana complejidad en Colombia
Keywords:
diabetes insípida, desequilibrio hidroelectrolítico, neurohipófisis, diabetes insipidus, water-electrolyte imbalance, pituitary gland, posteriorAbstract
Paciente masculino de 91 años de edad, exfumador y con antecedente patológico de Carcinoma Escamocelular en el párpado izquierdo; con cuadro clínico de 10 episodios de vómito y diarrea acuosa en múltiples oportunidades. Datos positivos al examen físico: deshidratación grado II. Según los resultados de los estudios paraclínicos se diagnostica Insuficiencia Renal Aguda. Por estos motivos se decide su ingreso y en los estudios realizados durante el mismo se observa elevación progresiva de los azoados, gasto urinario y desequilibrio hidrelectrolítico. Diagnosticándose diabetes insípida nefrogénica.
ABSTRACT
Male patient, 91-year-old ex-smoker with past history of Squamous Cell Carcinoma in the left eyelid; with clinical symptoms of 10 episodes of vomiting and watery diarrhea in multiple times. Positive data on physical examination: dehydration grade II. According to the results of paraclinical studies Acute renal failure was diagnosed. For these reasons admission is decided and laboratory tests showed: progressive increase of nitrogenous, urine output and water-electrolyte imbalance was observed. Nephrogenic diabetes insipidus was diagnosed.
References
2. Sterns RH. Disorders of Plasma Sodium — Causes, Consequences, and Correction. New England Journal of Medicine. 2015;372(1):55-65.
3. Danziger J, Zeidel ML. Osmotic Homeostasis. Clin J Am Soc Nephrol. 2015;10(5):852-62.
4. Knepper MA, Kwon T-H, Nielsen S. Molecular Physiology of Water Balance. New England Journal of Medicine. 2015;372(14):1349-58.
5. O’Carroll A-M, Lolait SJ, Harris LE, Pope GR. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol. 2013;219(1):R13-35.
6. Berl T. Vasopressin Antagonists. New England Journal of Medicine. 2015;372(23):2207-16.
7. Kortenoeven MLA, Fenton RA. Renal aquaporins and water balance disorders. Biochimica et Biophysica Acta (BBA) - General Subjects. 2014;1840(5):1533-49.
8. Bonfrate L, Procino G, Wang DQ-H, Svelto M, Portincasa P. A novel therapeutic effect of statins on nephrogenic diabetes insipidus. J Cell Mol Med. 2015;19(2):265-82.
9. Català Bauset M, Gilsanz Peral A, Tortosa Henzi F, Zugasti Murillo A, Moreno Esteban B, Halperin Ravinovich I, et al. Guía clínica del diagnóstico y tratamiento de los trastornos de la neurohipófisis. Endocrinología y Nutrición. 2007;54(1):23-33.
10. Di Iorgi N, Napoli F, Allegri AEM, Olivieri I, Bertelli E, Gallizia A, et al. Diabetes insipidus--diagnosis and management. Horm Res Paediatr. 2012;77(2):69-84.
11. Castro-Pretelt, M. J. Diabetes insípida nefrogénica inducida por litio: el papel de las aquoporinas. Salud Uninorte, 2005; 20: 59-6
Downloads
Published
How to Cite
Issue
Section
License
Those authors who have publications with this journal, accept the following terms:
The authors will retain their copyright and guarantee the journal the right of first publication of your work, which will be under a Creative license Commons Attribution-NonCommercial-ShareAlike 4.0 International . (CC BY-NC-SA 4.0).
The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (eg:deposit it in an institutional telemat