Lactiplantibacillus plantarum in the treatment of wounds
Keywords:
Lactiplantibacillus plantarum, probiotic, treatment, wounds.Abstract
Introduction: Lactiplantibacillus plantarum is a bacterium of the Lactobacillaceae family, capable of carrying out lactic fermentation. It is a well-characterized probiotic strain and is reported to possess many health benefits. It possesses antibacterial, antioxidant and wound healing properties. Objective: to describe the efficacy of Lactiplantibacillus plantarum in patients with wounds. Method: a review of the scientific literature was carried out using PubMed, Cinahl and Scopus databases. We selected 5 studies carried out in the last 5 years, with full text and adequate methodological quality. Results: Lactiplantibacillus plantarum seems to be effective as an adjuvant in surgical debridement for patients with complicated diabetic foot ulcers, in second degree burns, in burn infections, in accelerating the healing process of burns, wound healing, alternative to antibiotics in wounds infected by resistant bacteria and in wound epithelialization. Conclusions: although the evidence reviewed seems to indicate that positive results can be expected from the use of Lactiplantibacillus plantarum, the scarcity of scientific articles in this field and the small number of patients included in the studies is not sufficient to establish general recommendations. There is a need to increase the number of in vivo studies within this field and in this way it will be possible to offer patients the best care based on the latest demonstrated evidence.References
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2. Vizcaíno R, Macias Tomei C, Márquez S, Morales A, Torres N. Usos clínicos de los probioticos. Arch Venez Puer Ped. [Internet]. 2016 [acceso: 20/04/2023]; 79(1): 29-40. Disponible en: http://saber.ucv.ve/ojs/index.php/ revista_avpp/article/view/26717
3. Uriarte Mayorga DF, Gómez González BA. Probióticos ¿útiles en Dermatología? Dermatol Rev Mex [Internet]. 2020 [acceso: 20/04/2023]; 64(4): 483-486. Disponible en: https://dermatologiarevistamexicana.org.mx/article/ probioticos-utiles-en- dermatologia/
4. Mohtashami M, Mohamadi M, Azimi-Nezhad M, Saeidi J, Nia FF, Ghasemi A. Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors. Biotechnol Appl Biochem [Internet]. 2021; 68(6):1421-1431. DOI: 10.1002/bab.2064
5. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg [Internet]. 2021; 88: 105906. Disponible en: https:// doi.org/10.1016/j.ijsu.2021.105906
6. Mamédio C, Roberto M, Nobre C. The Pico Strategy for the Research Question. Rev latino-am Enferm [Internet]. 2007; 15(3):508-511. Disponible en: 10.1590/S0104-11692007000300023
7. Manterola C, Otze, T. Los sesgos en investigación clínica. Int. J. Morphol [Internet]. 2015; 33(3): 1156-1164. Disponible en: 10.4067/S0717-95022015000300056
8. Aguirrezabala IA, et. al. Metodología de la investigación y práctica clínica basada en la evidencia. Programa Transversal y Complementario del Residente (PTCR). España, Murcia: Consejería de Sanidad y Política Social de la Región de Murcia. [Internet]. 2012 [acceso: 11/04/2023]. Disponible en: https://www.murciasalud.es/recursos/ ficheros/258099-Metodologia_PTCR.pdf
9. Argañaraz Aybar JN, Ortiz Mayor S, Olea L, Garcia JJ, Nisoria S, Kolling Y, et al. Topical Administration of Lactiplantibacillus plantarum Accelerates the Healing of Chronic Diabetic Foot Ulcers through Modifications of Infection, Angiogenesis, Macrophage Phenotype and Neutrophil Response. Microorganisms [Internet]. 2022; 10(3): 634. DOI: 10.3390/microorganisms10030634
10. Soleymanzadeh Moghadam S, Momeni M, Mazar Atabaki S, Mousavi ShabestariT, Boustanshenas M, Afshar M, et al. Topical Treatment of Second- DegreeBurn Wounds with Lactobacillus plantarum Supernatant: Phase I Trial. Iran J Pathol [Internet]. 2022; 17(4): 460-468. DOI: 10.30699/ijp.2022.551202.2863
11. Moraffah F, Kiani M, Abdollahi M, Yoosefi S, Vatanara A, Samadi N. In Vitro- In Vivo Correlation for the Antibacterial Effect of Lactiplantibacillus plantarum as a Topical Healer for Infected Burn Wound. Probiotics Antimicrob Proteins [Internet]. 2022; 14(4): 675-689. https://doi.org/10.1007/s12602-022-09934-4
12. Soleymanzadeh Moghadam S, Mohammad N, Ghooshchian M, FathiZadeh S, Khodaii Z, Faramarzi M, Fagheei Aghmiyuni Z, et al. Comparison of the effects of Lactobacillus plantarum versus imipenem on infected burn wound healing. Med J Islam Repub Iran [Internet]. 2020;34: 94. DOI: 10.34171/mjiri.34.94
13. Moysidis M, Stavrou G, Cheva A, Abba Deka I, Tsetis JK, Birba V, et al. The 3-D configuration of excisional skin wound healing after topical probiotic appliction. Injury [Internet]. 2022; 53(4): 1385-1393. DOI: 10.1016/j.injury.2022.02.006
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Published
2023-10-18
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Sánchez Lozano J, Martínez Pizarro S. Lactiplantibacillus plantarum in the treatment of wounds. Rev 16 de abril [Internet]. 2023 Oct. 18 [cited 2024 Dec. 12];62:e1779. Available from: https://rev16deabril.sld.cu/index.php/16_04/article/view/1779
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