Solitary bone plasmocytoma, a rare monoclonal gammopathy. A Case report
Keywords:
Multiple Myeloma, Plasmacytoma, Paraparesis, ParaproteinemiasAbstract
Solitary bone plasmacytoma is a rare presenting plasma cell tumor that has been observed as a precursor to multiple myeloma; It is located mainly in the spine, causing pain at the thoracic and/or lumbar level. We report the case of a 55-year-old female patient who presented long-standing low back pain without associated trauma, accompanied by paraparesis; A chest X-ray was indicated, which revealed an osteolytic image, corresponding to a solitary bone plasmacytoma that was confirmed by histological examinations. After pharmacological treatment and radiotherapy, the evolution of the patient was satisfactory. Solitary bone plasmacytoma is a rare monoclonal gammopathy that should be suspected in the presence of axially located bone pain without a history of trauma associated with paraparesis. Its main differential diagnosis is multiple myeloma, which is sometimes the final result of its evolution.
References
Bladé Creixentí J, San Miguel JF. Gammapatías monoclonales. En: Rozman C, Cardellach López F. Farreras Rozman Medicina interna. Vol 2. 19ª ed. Barcelona: Elsevier; 2020. p. 1619-1628.
Fernández A, Sancho M, Gras J, Talavera J. Plasmocitoma solitario de cabeza y cuello. Presentación de tres casos y revisión de la literatura. Act Otorrinolaringol Esp [Internet]. 2001 [citado: 19/09/2021]; 52(8):715-720. Disponible en: https://doi.org/10.1016/S0001-6519(01)78271-4
Chacha N, Vera J, Ramírez F, Chisesi T, Posligua K. Plasmocitoma óseo solitario: caso clínico. Rev Oncol Ecu [Internet] 2020 [citado en: 20/09/2021]; 30(1): 24–30. https://doi.org/10.33821/468
Gil Agramonte M, Serrano Mirabal J, Machín García S, Rivera Keelling C, Valdés Cabrera F, González Otero A et al. Plasmocitoma solitario en pediatría: una rara entidad. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2017 [citado: 20/09/2021] ; 33( 3 ): 102-107. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-02892017000300012&lng=es
Muñoz-Medina CE, Alemán-Frías LD, Moreno-Brito RN, Fleitas-Moreno MP., Yépez-González PJ, Soto-Alfaro TV. Plasmocitoma óseo solitario coxofemoral. Presentación de un caso. Revista argentina de medicina [Internet]. 2019 [citado: 20/09/2021]; 7(2):109-112. Disponible en: http://revistasam.com.ar/index.php/RAM/article/view/304
Montoya-Castillo M. Plasmocitoma óseo solitario en la pared torácica: una manifestación inusual y una bomba de tiempo. Revista de Hematología [Internet] 2020 [citado: 20/09/2021] ; 21(2): 115-119.Disponible en: https://doi.org/10.24245/rev_hematol.v21i2.3588
Medina Pérez VM, Vasallo Díaz AL, Peñate Tamayo FD. Plasmocitoma solitario extramedular de órbita con extensión al seno maxilar. Medicentro Electrónica [Internet]. 2017 [citado: 20/09/2021] ; 21( 4 ): 351-355. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432017000400011&lng=es.
Zumaeta J, Lazón M, Murga A. Plasmocitoma solitario intracraneal: Reporte de caso. Peru J Neurosurg [Internet] 2021 [citado: 20/09/2021]; 3(1): 37-40. Disponible en: http://perujournalneurosurgery.org/sites/default/files/PLASMOCITOMA%20SOLITARIO%20INTRACRANEAL%20REPORTE%20%20DE%20CASO%20Spanish.pdf
Pham A, Mahindra A. Solitary Plasmacytoma: a review of diagnosis and management. Curr Hematol Malig Rep [Internet]. 2019 [citado: 20/09/2021];14(2):63-69. https://doi.org/10.1007/s11899-019-00499-8
Gálvez-Prieto F, Lorenzo-Franco F, Luaces-Rey R, López-Cedrún Cembranos JL. ¿Cuál es su diagnóstico?. Rev Esp Cirug Oral y Maxilofac [Internet]. 2019 [citado: 20/09/2021] ; 41( 4 ): 202-205. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-05582017000100050&lng=es
Xie L, Wang H, Jiang J. Does radiotherapy with surgery improve survival and decrease progression to multiple myeloma in patients with solitary plasmacytoma of bone of the spine? World Neurosurg [Internet] 2020 [citado: 20/09/2021];134(1):e790-e798. Disponible en: https://doi.org/10.1016/j.wneu.2019.11.002
Salguero AJ, Cuneo BN, Olguín HF, Osse ME, Villanueva IME. Plasmocitoma solitario de costilla como presentación inicial de mieloma múltiple: reporte de un caso. Rev Cir. [Internet]. 2019 [citado: 20/09/2021]; 71(4):341-344. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S2452-45492019000400341&lng=es
Grammatico S, Scalzulli E, Petrucci MT. Solitary Plasmacytoma. Mediterr J Hematol Infect Dis [Internet]. 2017 [citado: 20/09/2021]; 9(1):e2017052. Disponible en: https://doi.org/10.4084/MJHID.2017.052
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, et al. Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol [Internet]. 2018 [citado en 20/09/2021]; 11(1):10-16. https://doi.org/10.1186/s13045-017-0549-1
Tsang RW, Campbell BA, Goda JS, Kelsey CR, Kirova YM, Parikh RR, et al. Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines From the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys [Internet]. 2018 [citado en: 20/09/2021]; 101(4):794-808. Disponible en: https://doi.org/10.1016/j.ijrobp.2018.05.009
Mheidly K, Lamy De La Chapelle T, Hunault M, Benboubker L, Benchalal M, Moreau P, et al. New insights in the treatment of patients with solitary bone plasmacytoma. Leuk Lymphoma [Internet]. 2019 [citado en: 20/09/2021]; 60(11):2810-2813. Disponible en: https://doi.org/10.1080/10428194.2019.1605067
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