Implications of physiological changes in pregnancy in COVID-19

Rolando Dario Rosales-Campos, Héctor José Pérez-Hernández, Soraida Cándida Acosta-Brooks

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Pregnant women generally constitute a group at high risk of infectious diseases due to gestational immunological and physiological changes in their system. That is why the objective of this work is to analyze the implications of the physiological changes of pregnancy in SARS-CoV-2 disease. Physiological changes in pregnant women not only increase their susceptibility to the virus, but also increase the severity of the disease. Changes in the respiratory and immune systems, the role of the placenta in coagulation, and the function of endothelial cells are the physiological changes that most influence the disease. The decrease in lung capacity and the variations that occur in the immune system represent new treatment challenges for pregnant women with COVID-19 disease and therefore new areas of research limited so far.

Palabras clave

Pregnancy; Covid-19; SARS-Cov-2.


Rajewska A, Mikołajek-Bedner W, Lebdowicz-Knul J, Sokołowska M, Kwiatkowski S, Torbé A. COVID-19 and pregnancy - where are we now? A review. J Perinat Med [Internet]. 2020 [cited 02/08/2021]; 48(5):428-34. Available from:

Zhao X, Jiang Y, Zhao Y, Xi H, Liu C, Qu F, et al. Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening. Eur J Clin Microbiol Infect Dis [Internet]. 2020 [cited 02/08/2021]; 39(7):1209-20. Available from:

Thompson JL, Nguyen LM, Noble KN, Aronoff DM. COVID-19-related disease severity in pregnancy. Am J Reprod Immunol [Internet]. 2020 [cited 02/08/2021]; 84(5):e13339. Available from: .

Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiol Rev [Internet]. 2021 [cited 02/08/2021]; 101(1):303-18. Available from:

Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med [Internet]. 2020 [cited 02/08/2021]; 48(9):950-58. Available from:

Chilipio-Chiclla MA, Campos-Correa KE. Manifestaciones clínicas y resultados materno-perinatales del COVID-19 asociado al embarazo: Una revisión sistemática. Rev Inter Sal Mat Fet [Internet]. 2020 [cited 02/08/2021]; 5(2):24-37. Disponible en:

Muyayalo KP, Huang DH, Zhao SJ, Xie T, Mor G, Liao AH. COVID-19 and Treg / Th17 imbalance: Potential relationship to pregnancy outcomes. Am J Reprod Immunol[Internet]. 2020 [cited 02/08/2021]; 84(5):e13304. Available from:

Wenling Y, Junchao Q, Xiao Z, Ouyang S. Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo [Internet]. 2020 [cited 02/08/2021]; 62:e62. Available from:

Salem D, Katranji F, Bakdash T. Covid-19 infection in pregnant women: Review of maternal and fetal outcomes. Int. J. Gynecol. Obstet [Internet]. 2021 [cited 02/08/2021]; 152(3):291-8. Available from:

Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol [Internet]. 2020 [cited 02/08/2021]; 84(5):e13306. Available from:

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